1. osnaDocs
  2. Fachbereich 05 - Biologie / Chemie
  3. FB05 - E-Dissertationen

Ion Channel (mimetic) Sensors : Mechanism of Charge Propagation through Thiol-, Protein- and Dendrimer-Modified Electrodes

Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2005122214
Open Access logo originally created by the Public Library of Science (PLoS)
Langanzeige der Metadaten
DC ElementWertSprache
dc.contributor.advisorProf. Dr. Lorenz Walder
dc.creatorDegefa, Tesfaye Hailu
dc.date.accessioned2010-01-30T14:43:15Z
dc.date.available2010-01-30T14:43:15Z
dc.date.issued2005-12-22T18:59:09Z
dc.date.submitted2005-12-22T18:59:09Z
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2005122214-
dc.description.abstractThe mechanism of ion channel (mimetic) sensors (ICSs) consisting of (poly)electrolyte type alkane thiol, protein or dendrimer self assembled monolayers (SAMs) at gold electrodes as a sensing layer and highly charged redox-active marker ions in solution was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and rotating disk voltammetry (RDV) in the presence of a series of analytes, i.e, suppressor and enhancer ions, leading to the following general statements: (i) electrostatic binding of marker ions to the sensing layer is a prerequisite for an electrochemical current and (ii) charge propagation through the layer consists of electron hopping between surface-confined marker ions and solution born marker ions. It is further shown that there exists (iii) competition between equally charged ions for coordination sites at the oppositely charged sensing layer. An apparent charge inversion (iv) by surface confinement of multiple charged counter ions occurs. Thereby an existing electron transfer (ET) path can be cut or a new one can be induced. Build up of a second layer of multiple charged electroactive ions (v) can take place on top of the charge inverted layer. Competing ET (vi) through the inner and outer redox layer can take place. In addition to fundamental insight into the mechanism of charge propagation, valuable information for the design, optimization, and tailoring of new biosensors based on the ICS concept, the possibilities of exploiting layer-by-layer electrostatic SAMs and dendrimer-DNA interaction for bioanalytical applications are demonstrated by the current findings.eng
dc.language.isoeng
dc.subjectSelf assembled monolayer
dc.subjectMarker ions
dc.subjectElectrostatic interactions
dc.subjectElectron transfer catalysis
dc.subjectIon channel (mimetic) sensors
dc.subject.ddc670 - Industrielle Fertigungger
dc.titleIon Channel (mimetic) Sensors : Mechanism of Charge Propagation through Thiol-, Protein- and Dendrimer-Modified Electrodeseng
dc.typeDissertation oder Habilitation [doctoralThesis]-
thesis.locationOsnabrück-
thesis.institutionUniversität-
thesis.typeDissertation [thesis.doctoral]-
thesis.date2005-12-15T12:00:00Z-
elib.elibid511-
elib.marc.edtfangmeier-
elib.dct.accessRightsa-
elib.dct.created2005-12-21T16:09:50Z-
elib.dct.modified2005-12-22T18:59:09Z-
dc.contributor.refereeProf. Philippe Buhlmann
dc.subject.bk30.14ger
dc.subject.dnb30 - Chemieger
vCard.ORGFB5ger
Enthalten in den Sammlungen:FB05 - E-Dissertationen

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
E-Diss511_thesis.pdfPräsentationsformat1,87 MBAdobe PDF
E-Diss511_thesis.pdf
Miniaturbild
Öffnen/Anzeigen
Zur Kurzanzeige


Alle Ressourcen im Repositorium osnaDocs sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt. rightsstatements.org