Investigation of yeast and Drosophila ARF proteins and their associated GEFs expressed in Saccharomyces cerevisiae
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https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-201101177664
https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-201101177664
Title: | Investigation of yeast and Drosophila ARF proteins and their associated GEFs expressed in Saccharomyces cerevisiae |
Authors: | Buchwald, Ulf |
Thesis advisor: | Prof. Dr. Jürgen J. Heinisch |
Thesis referee: | Prof. Dr. Achim Paululat |
Abstract: | The ADP-ribosylation factor (ARF) family of small G-proteins regulates membrane dynamics and intracellular membrane traffic. ARFs are activated upon GTP-binding catalyzed by guanine-nucleotide exchange factors (GEF), which works as a molecular switch and triggers association with specific target membranes. This work focused on the cloning, expression and characterization of genes from the milk yeast K. lactis and the fly D. melanogaster, which are putative homologs of the S. cerevisiae genes GEA1, GEA2, ARF1, ARF2, and ARF3. |
URL: | https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-201101177664 |
Subject Keywords: | Yeast; Drosophila; ARF; GEF; Proteins |
Issue Date: | 17-Jan-2011 |
Type of publication: | Dissertation oder Habilitation [doctoralThesis] |
Appears in Collections: | FB05 - E-Dissertationen |
Files in This Item:
File | Description | Size | Format | |
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thesis_buchwald.pdf | Präsentationsformat | 3,75 MB | Adobe PDF | thesis_buchwald.pdf View/Open |
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