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Modulation of fear extinction by stress, stress hormones and estradiol: a review

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https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2016020814228
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dc.creatorStockhorst, Ursula
dc.creatorAntov, Martin
dc.date.accessioned2016-02-08T11:13:24Z
dc.date.available2016-02-08T11:13:24Z
dc.date.issued2016-02-08T11:13:24Z
dc.identifier.citationFrontiers in Behavioral Neuroscience, 2016, 9:359
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2016020814228-
dc.description.abstractFear acquisition and extinction are valid models for the etiology and treatment of anxiety, trauma- and stressor-related disorders. These disorders are assumed to involve aversive learning under acute and/or chronic stress. Importantly, fear conditioning and stress share common neuronal circuits. The stress response involves multiple changes interacting in a time-dependent manner: (a) the fast first-wave stress response [with central actions of noradrenaline, dopamine, serotonin, corticotropin-releasing hormone (CRH), plus increased sympathetic tone and peripheral catecholamine release] and (b) the second-wave stress response [with peripheral release of glucocorticoids (GCs) after activation of the hypothalamus-pituitary-adrenocortical (HPA) axis]. Control of fear during extinction is also sensitive to these stress-response mediators. In the present review, we will thus examine current animal and human data, addressing the role of stress and single stress-response mediators for successful acquisition, consolidation and recall of fear extinction. We report studies using pharmacological manipulations targeting a number of stress-related neurotransmitters and neuromodulators [monoamines, opioids, endocannabinoids (eCBs), neuropeptide Y, oxytocin, GCs] and behavioral stress induction. As anxiety, trauma- and stressor-related disorders are more common in women, recent research focuses on female sex hormones and identifies a potential role for estradiol in fear extinction. We will thus summarize animal and human data on the role of estradiol and explore possible interactions with stress or stress-response mediators in extinction. This also aims at identifying time-windows of enhanced (or reduced) sensitivity for fear extinction, and thus also for successful exposure therapy.eng
dc.relationhttp://journal.frontiersin.org/article/10.3389/fnbeh.2015.00359/full
dc.rightsNamensnennung 4.0 International-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectfear extinctioneng
dc.subjectstresseng
dc.subjectmonoamineseng
dc.subjectglucocorticoidseng
dc.subjectopioidseng
dc.subjectendocannabinoidseng
dc.subjectestradioleng
dc.subjectexposure therapyeng
dc.subject.ddc150 - Psychologie
dc.subject.ddc570 - Biowissenschaften; Biologie
dc.titleModulation of fear extinction by stress, stress hormones and estradiol: a revieweng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [article]
dc.subject.bk77.05 - Experimentelle Psychologie
dc.subject.bk77.34 - Lernpsychologie
dc.subject.bk77.50 - Psychophysiologie
dc.identifier.doi10.3389/fnbeh.2015.00359
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