COGcollator: a web server for analysis of distant relationships between homologous protein families

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dc.creatorDibrova, Daria V.-
dc.creatorKonovalov, Kirill A.-
dc.creatorPerekhvatov, Vadim V.-
dc.creatorSkulachev, Konstantin V.-
dc.creatorMulkidjanian, Armen Y.-
dc.date.accessioned2018-04-30T09:07:19Z-
dc.date.available2018-04-30T09:07:19Z-
dc.date.issued2018-04-30T09:07:19Z-
dc.identifier.citationBiology Direct 12:29 (2017). BioMedCentral-
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2018043016947-
dc.description.abstractBackground: The Clusters of Orthologous Groups (COGs) of proteins systematize evolutionary related proteins into specific groups with similar functions. However, the available databases do not provide means to assess the extent of similarity between the COGs. Aim: We intended to provide a method for identification and visualization of evolutionary relationships between the COGs, as well as a respective web server. Results: Here we introduce the COGcollator, a web tool for identification of evolutionarily related COGs and their further analysis. We demonstrate the utility of this tool by identifying the COGs that contain distant homologs of (i) the catalytic subunit of bacterial rotary membrane ATP synthases and (ii) the DNA/RNA helicases of the superfamily 1eng
dc.relationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706428/pdf/13062_2017_Article_198.pdf-
dc.rightsNamensnennung 4.0 International-
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/-
dc.subjectClusters of orthologous groups of proteinseng
dc.subjectPhylogenomic analysiseng
dc.subjectComparative genomicseng
dc.subjectOthologseng
dc.subjectParalogseng
dc.subjectATP synthaseeng
dc.subjectDNA/RNA helicaseseng
dc.subject.ddc570 - Biowissenschaften, Biologie-
dc.titleCOGcollator: a web server for analysis of distant relationships between homologous protein familieseng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [article]ger
dc.identifier.doi10.1186/s13062-017-0198-x-
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