1. osnaDocs
  2. Fachbereich 05 - Biologie / Chemie
  3. FB05 - Hochschulschriften

Alterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stress

Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-201904101484
Open Access logo originally created by the Public Library of Science (PLoS)
Langanzeige der Metadaten
DC ElementWertSprache
dc.creatorAmbrée, Oliver-
dc.creatorRuland, Christina-
dc.creatorScheu, Stefanie-
dc.creatorArolt, Volker-
dc.creatorAlferink, Judith-
dc.date.accessioned2019-04-10T15:50:28Z-
dc.date.available2019-04-10T15:50:28Z-
dc.date.issued2018-07-13-
dc.identifier.citationFrontiers in Behavioral Neuroscience Vol. 12, Article 141, Frontiers Media, 2018, S. 1-12, doi: 10.3389/fnbeh.2018.00141ger
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-201904101484-
dc.description.abstractDysregulation of innate immune responses has frequently been reported in stressassociated psychiatric disorders such as major depression. In mice, enhanced circulating cytokine levels as well as altered innate immune cell numbers have been found after stress exposure. In addition, stress-induced recruitment of peripheral monocytes to the brain has been shown to promote anxiety-like behavior. However, it is yet unclear whether specific differences in the innate immune system are associated with stress susceptibility or resilience in mice. Utilizing chronic social defeat, a model of depression and stress vulnerability, we characterized peripheral and brain-invading myeloid cells in stress-susceptible and resilient animals. In all defeated animals, we found reduced percentages of CD11cC dendritic cells (DCs) by flow cytometry in the spleen when compared to non-defeated controls. Exclusively in susceptible mice conventional DCs of the spleen showed up-regulated expression of MHC class II and co-stimulatory CD80 molecules pointing toward an enhanced maturation phenotype of these cells. Susceptible, but not resilient animals further exhibited an increase in inflammatory Ly6Chi monocytes and higher numbers of spleen-derived CD11bC cells that produced the proinflammatory cytokine tumor necrosis factor (TNF) upon lipopolysaccharide (LPS) stimulation. Increased percentages of peripheral CD45hi CD11bC cells immigrated into the brain of defeated mice, regardless of resilience or susceptibility. However, cellular infiltrates in the brain of susceptible mice contained higher percentages of CC chemokine receptor 2 (CCR2C) Ly6Chi monocytes representing an inflammatory phenotype. Thus, we defined specific stress-related immune signatures involving conventional DCs and inflammatory Ly6Chi monocytes in susceptible and resilient mice. Together, our findings suggest an impact of the innate immune system in vulnerability to stress-related disorders such as major depression.eng
dc.relationhttps://doi.org/10.3389/fnbeh.2018.00141ger
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectchronic stresseng
dc.subjectsocial defeateng
dc.subjectsusceptibilityeng
dc.subjectresilienceeng
dc.subjectmyeloid cellseng
dc.subjectmajor depressive disorder (MDD)eng
dc.subjectmonocyteseng
dc.subjectdendritic cellseng
dc.subject.ddc570 - Biowissenschaften, Biologieger
dc.titleAlterations of the Innate Immune System in Susceptibility and Resilience After Social Defeat Stresseng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [article]ger
dc.identifier.doi10.3389/fnbeh.2018.00141-
Enthalten in den Sammlungen:FB05 - Hochschulschriften
Open-Access-Publikationsfonds

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
fnbeh_12_141_2018_Ambrée.pdfResearch article2,49 MBAdobe PDF
fnbeh_12_141_2018_Ambrée.pdf
Miniaturbild
Öffnen/Anzeigen
Zur Kurzanzeige


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons