1. osnaDocs
  2. Fachbereich 08 - Humanwissenschaften
  3. FB08 - Hochschulschriften

MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors

Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
https://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202105144644
Open Access logo originally created by the Public Library of Science (PLoS)
Langanzeige der Metadaten
DC ElementWertSprache
dc.creatorMelnik, Bodo-
dc.creatorJohn, Swen Malte-
dc.creatorCarrera-Bastos, Pedro-
dc.creatorSchmitz, Gerd-
dc.date.accessioned2021-05-14T10:59:34Z-
dc.date.available2021-05-14T10:59:34Z-
dc.date.issued2020-07-29-
dc.identifier.citationMelnik, B.C.; John, S.M.; Carrera-Bastos, P.; Schmitz, G. MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors. Cancers 2020, 12, 2111.ger
dc.identifier.urihttps://osnadocs.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202105144644-
dc.description.abstractDNA mutation-induced activation of RAS-BRAF-MEK-ERK signaling associated with intermittent or chronic ultraviolet (UV) irradiation cannot exclusively explain the excessive increase of malignant melanoma (MM) incidence since the 1950s. Malignant conversion of a melanocyte to an MM cell and metastatic MM is associated with a steady increase in microRNA-21 (miR-21). At the epigenetic level, miR-21 inhibits key tumor suppressors of the RAS-BRAF signaling pathway enhancing proliferation and MM progression. Increased MM cell levels of miR-21 either result from endogenous upregulation of melanocytic miR-21 expression or by uptake of miR-21-enriched exogenous exosomes. Based on epidemiological data and translational evidence, this review provides deeper insights into environmentally and metabolically induced exosomal miR-21 trafficking beyond UV-irradiation in melanomagenesis and MM progression. Sources of miR-21-enriched exosomes include UV-irradiated keratinocytes, adipocyte-derived exosomes in obesity, airway epithelium-derived exosomes generated by smoking and pollution, diet-related exosomes and inflammation-induced exosomes, which may synergistically increase the exosomal miR-21 burden of the melanocyte, the transformed MM cell and its tumor environment. Several therapeutic agents that suppress MM cell growth and proliferation attenuate miR-21 expression. These include miR-21 antagonists, metformin, kinase inhibitors, beta-blockers, vitamin D, and plant-derived bioactive compounds, which may represent new options for the prevention and treatment of MM.eng
dc.relationhttps://doi.org/10.3390/cancers12082111ger
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectenvironmenteng
dc.subjectepigeneticseng
dc.subjectexosomeeng
dc.subjectmelanomaeng
dc.subjectmetabolic syndromeeng
dc.subjectmicroRNA-21eng
dc.subjectpreventioneng
dc.subjectobesityeng
dc.subjectradiationeng
dc.subjecttherapyeng
dc.subject.ddc610 - Medizin, Gesundheitger
dc.titleMicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factorseng
dc.typeEinzelbeitrag in einer wissenschaftlichen Zeitschrift [article]ger
orcid.creatorhttps://orcid.org/0000-0002-4501-1809-
orcid.creatorhttps://orcid.org/0000-0002-1325-1007-
orcid.creatorhttps://orcid.org/0000-0001-5406-9458-
orcid.creatorhttps://orcid.org/0000-0002-4218-1300-
dc.identifier.doi10.3390/cancers12082111-
Enthalten in den Sammlungen:FB08 - Hochschulschriften
Open-Access-Publikationsfonds

Dateien zu dieser Ressource:
Datei Beschreibung GrößeFormat 
cancers_Melnik_etal_2020.pdf2,4 MBAdobe PDF
cancers_Melnik_etal_2020.pdf
Miniaturbild
Öffnen/Anzeigen
Zur Kurzanzeige


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons